Erken Çevrimiçi makaleler [English]

    MELASMA TEDAVİSİNDE% 4 KOJİK ASİT İLE% 5 METHİMAZOL KREM KULLANIMININ KARŞILAŞTIRILMASI

    Satya Yenny1

    1Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia., Head of Cosmetic Dermatology Division Department of Skin Health and Genitals, , Padang


    Objective:This research aims to assess the effectiveness, patient satisfaction, and adverse effects of non-hydroquinone therapy with 5% methimazole cream compared with that using 4% kojic acid for treatment of melasma. Methods:A single-blind study of 45 patients with melasma, comparing right-and left-sided treatment with 5% methimazole cream and 4% nighttime kojic acid in a random order was conducted. In the morning and afternoon, SPF 30 sunscreen was used. The evaluation was carried out every 2 weeks by assessing the Melasma Area and Severity Index (MASI), mexameter index, patient satisfaction, and side effects. Results:Decreases in the MASI score and amount of pigment were greater using 5% methimazole cream than with kojic acid 4%. Patient satisfaction concerning the use of 5% methimazole cream was higher than with 4% kojic acid. Adverse effects were mostly found with the use of methimazole 5% cream.Conclusion:Comparison of the MASI score, amount of pigment, and patient satisfaction scales found the use of 5% methimazole cream to be superior to that of 4% kojic acid. Five percent methimazole cream can be used as an alternative therapy in the treatment of melasma.